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dc.contributor.author김경수-
dc.date.accessioned2018-05-03T04:56:30Z-
dc.date.available2018-05-03T04:56:30Z-
dc.date.issued2016-11-
dc.identifier.citationColloids and Surfaces B: Biointerfaces, v. 150, Page. 216-222en_US
dc.identifier.issn0927-7765-
dc.identifier.issn1873-4367-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776516308335-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/71288-
dc.description.abstractThe objective of this study was to develop a novel solid self-nanoemulsifying drug delivery system (SNEDDS) using a membrane emulsification technique involving Shirasu porous glass (SPG) which produced very small and uniform emulsion droplets, resulting in enhanced solubility, dissolution and oral bioavailability of poorly water-soluble cilostazol. The effects of carriers on the drug solubility were assessed, and pseudo-ternary phase diagrams were plotted. Among the liquid SNEDDS formulations tested, the liquid SNEDDS composed of peceol (oil), Tween 20 (surfactant) and Labrasol (cosurfactant) at a weight ratio of 15/55/30, produced the smallest emulsion droplet size. The cilostazol-loaded liquid SNEDDS formulation was suspended in the distilled water and subjected to SPG membrane emulsification. Calcium silicate was added as a solid carrier in this liquid SNEDDS, completely suspended and spray-dried, leading to the production of a cilostazol-loaded solid SNEDDS. The emulsion droplet size, solubility and dissolution of the emulsified solid SNEDDS were assessed as compared to the solid SNEDDS prepared without emulsification. Moreover, the physicochemical characteristics and pharmacokinetics in rats were evaluated with the emulsified solid SNEDDS. The emulsified solid SNEDDS provided significantly smaller and more uniform nanoemulsions than did the non-emulsified solid SNEDDS. The emulsified solid SNEDDS showed significantly higher drug solubility and dissolution as compared to the non-emulsified solid SNEDDS. The crystalline drug in it was converted into the amorphous state. Moreover, in rats, it gave significantly higher initial plasma concentrations and AUC compared to the drug powder, suggesting its improved oral bioavailability of cilostazol. Thus, this novel solid SNEDDS developed using a membrane emulsification technique represents a potentially powerful oral delivery system for cilostazol. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation (NRF) of South Korea grants funded by the South Korea government (MEST) (Nos. 2015R1A2A2A05027872 & 2015R1A2A2A01004118) and a grant (16173MFDS542) from the Ministry of Food and Drug Safety in 2016.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectCilostazolen_US
dc.subjectSolid self-nanoemulsifying drug delivery systemen_US
dc.subjectShirasu porous glass membraneen_US
dc.subjectMembrane emulsificationen_US
dc.subjectEmulsion droplet sizeen_US
dc.subjectSolubilityen_US
dc.subjectBioavailabilityen_US
dc.subjectDRUG-DELIVERY SYSTEMen_US
dc.subjectENHANCED ORAL BIOAVAILABILITYen_US
dc.subjectWATER-SOLUBLE CILOSTAZOLen_US
dc.subjectCLOPIDOGREL NAPADISILATEen_US
dc.subjectBEAGLE DOGSen_US
dc.subjectFENOFIBRATEen_US
dc.subjectDISSOLUTIONen_US
dc.subjectSOLUBILITYen_US
dc.subjectDISPERSIONen_US
dc.subjectSMEDDSen_US
dc.titleDevelopment of novel cilostazol–loaded solid SNEDDS using a SPG membrane emulsification technique: Physicochemical characterization and in vivo evaluationen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.colsurfb.2016.11.039-
dc.relation.page216-222-
dc.relation.journalColloids and Surfaces B: Biointerfaces-
dc.contributor.googleauthorMustapha, Omer-
dc.contributor.googleauthorKim, Kyung Soo-
dc.contributor.googleauthorShafique, Shumaila-
dc.contributor.googleauthorKim, Dong Shik-
dc.contributor.googleauthorJin, Sung Giu-
dc.contributor.googleauthorSeo, Youn Gee-
dc.contributor.googleauthorYoun, Yu Seok-
dc.contributor.googleauthorOh, Kyung Taek-
dc.contributor.googleauthorLee, Beom-Jin-
dc.contributor.googleauthorPark, Young Joon-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorChoi, Han-Gon-
dc.relation.code2016023987-
dc.sector.campusE-
dc.sector.daehakRESEARCH INSTITUTE[E]-
dc.sector.departmentINSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY-
dc.identifier.pidsoyo79-
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RESEARCH INSTITUTE[E](부설연구소) > INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY(약학기술연구소) > Articles
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