68 0

Asymmetric Domino Multicatalysis for the Synthesis of 3-Substituted Phthalides: Cinchonine/NHC Cooperative System

Title
Asymmetric Domino Multicatalysis for the Synthesis of 3-Substituted Phthalides: Cinchonine/NHC Cooperative System
Other Titles
NHC Cooperative System
Author
윤소원
Keywords
N-HETEROCYCLIC CARBENE; CATALYTIC KINETIC RESOLUTION; ENANTIOSELECTIVE SYNTHESIS; NONADJACENT STEREOCENTERS; QUATERNARY STEREOCENTERS; CINCHONA ALKALOIDS; AROMATIC-ALDEHYDES; CASCADE CATALYSIS; NHC; ORGANOCATALYSTS
Issue Date
2014-02
Publisher
THE AMERICAN CHEMICAL SOCIETY
Citation
ORGANIC LETTERS, Vol.16 No.3 [2014], 1028-1031
Abstract
It is demonstrated that two organocatalysts, achiral NHC and chiral bifunctional cinchonine, are mutually compatible and operating concurrently and effectively to promote the asymmetric domino oxidation/oxa-Michael addition reaction. This protocol allowed access to both enantiomers of a product by using two natural, inexpensive pseudoenantiomeric cinchona alkaloids, cinchonine and cinchonidine, as well as to phthalides containing a chiral quaternary carbon center in good enantioselectivities.
URI
https://pubs.acs.org/doi/10.1021/ol5000617http://repository.hanyang.ac.kr/handle/20.500.11754/70756
ISSN
1523-7060; 1523-7052
DOI
10.1021/ol5000617
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE