Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진기 | - |
dc.date.accessioned | 2018-04-24T05:55:39Z | - |
dc.date.available | 2018-04-24T05:55:39Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 512, No. 1, Page. 314-321 | en_US |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517316308171 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/70366 | - |
dc.description.abstract | We investigated how to overcome problems associated with the solubility, dissolution, and oral bioavailability of the poorly water-soluble drug compound, chrysosplenol C (CRSP), as well as the effects of single and binary hydrophilic polymers (PVP K-25 and/or PEG 6000) on the solubility and dissolution parameters of CRSP. Then an optimized formulation was further developed with a surfactant. To select a surfactant suitable for a CRSP-loaded solid dispersion (SD), the solubility of CRSP in distilled water containing 1% surfactant was compared with the solubilities in other surfactants. Sodium lauryl sulfate (SLS) showed the highest drug solubility. Overall, a formulation containing CRSP, binary hydrophilic polymers (PVP and PEG 6000), and SLS at a ratio of 2.0/0.2/1.1/0.7 showed the optimum in vitro release profile. This optimized formulation had better safety properties than pure CRSP in cell viability examinations. SD formulations were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), and Fourier-transform infrared (FT-IR) spectroscopy. Our optimized SD formulation is expected to improve the bioavailability of CRPS because it improves the solubility and dissolution rate of CRSP. (C) 2016 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Korea government, MSIP (No. 2015R1A2A1A10051596) and MOE (No. 2009-0093815). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Chrysosplenol C | en_US |
dc.subject | Solid dispersion | en_US |
dc.subject | Dissolution | en_US |
dc.subject | Hydrophilic carrier | en_US |
dc.subject | WATER-SOLUBLE DRUGS | en_US |
dc.subject | DISSOLUTION PROPERTIES | en_US |
dc.subject | MILIUSA-BALANSAE | en_US |
dc.subject | SURFACE-AREA | en_US |
dc.subject | RELEASE | en_US |
dc.subject | BIOAVAILABILITY | en_US |
dc.subject | IMPROVEMENT | en_US |
dc.subject | NIMODIPINE | en_US |
dc.subject | STABILITY | en_US |
dc.title | Solubilization and formulation of chrysosplenol C in solid dispersion with hydrophilic carriers | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 512 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2016.08.062 | - |
dc.relation.page | 314-321 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.contributor.googleauthor | Ng, CL | - |
dc.contributor.googleauthor | Lee, SE | - |
dc.contributor.googleauthor | Lee, JK | - |
dc.contributor.googleauthor | Kim, TH | - |
dc.contributor.googleauthor | Jang, WS | - |
dc.contributor.googleauthor | Choi, JS | - |
dc.contributor.googleauthor | Kim, YH | - |
dc.contributor.googleauthor | Kim, JK | - |
dc.contributor.googleauthor | Park, JS | - |
dc.relation.code | 2016002676 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | jinkikim | - |
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