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Does brachydactyly have a protective effect on the erosive changes in rheumatoid arthritis?

Title
Does brachydactyly have a protective effect on the erosive changes in rheumatoid arthritis?
Author
방소영
Keywords
Rheumatoid arthritis; Brachydactyly; HOXD gene
Issue Date
2012-05
Publisher
Elsevier Science B.V., Amsterdam.
Citation
JOINT BONE SPINE, 2012, 79(3), P.271-273
Abstract
OBJECTIVE:Brachydactyly (BD) is a general term for inappropriately short fingers and/or toes. The author previously reported that a short metacarpal bone had a protective effect on the metacarpophalangeal joint of the same finger in rheumatoid arthritis (RA). The objective was to investigate the prevalence of BD in patients with RA and its potential effect on the phenotype, especially erosive changes.METHODS:A total of 1524 Korean patients with RA were recruited. The presence of BD on hand radiographs, rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP), HLA-DRB1 shared epitopes (SE), risk haplotypes of peptidyl deiminase type IV (PADI4) and erosive joint stage, and smoking status, were determined.RESULTS:The prevalence of BD was 7.9% (n=120) in our RA cohort. The types of BD were type A3 (79.2%), type D (15.0%), Kirner deformity (14.2%), and type E (6.7%). RA patients with BD had reduced erosion on hand radiographs (OR=0.57, 95% CI: 0.34-0.95, p=0.029) adjusted for age, sex, disease duration, smoking, RF, anti-CCP, SE, and PADI4.CONCLUSION:BD is more common in RA patients than might be expected. BD may have a protective effect on erosive changes in RA independent of previously well-established risk factors such as seropositivity, SE, PADI4, and smoking.
URI
https://www.sciencedirect.com/science/article/pii/S1297319X11001448?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/70057
ISSN
1297-319X
DOI
10.1016/j.jbspin.2011.05.022
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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