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Effect of Mycophenolic Acid on Cyclosporin A-Induced Fibronectin Expression in Rat Mesangial Cells

Title
Effect of Mycophenolic Acid on Cyclosporin A-Induced Fibronectin Expression in Rat Mesangial Cells
Author
박준성
Keywords
Cyclosporin; Fibrosis; Transforming growth factor-beta; Smad proteins
Issue Date
2013-01
Publisher
S. Karger AG
Citation
Pharmacology, 2013, 91(1-2), P.20-28
Abstract
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of cyclosporin A (CsA) and, if so, to determine the molecular mechanisms involved. The effect of MPA treatment on CsA-induced signaling through the transforming growth factor-beta (TGF-beta)/Smad pathway was evaluated by immunoblot analysis in cultured primary rat mesangial cells. Treatment of cells with 1 mu mol/l MPA did not significantly decrease the CsA-induced expression of TGF-beta(1), but partially reversed the increases in Smad3 phosphorylation and fibronectin (FBN) production, and increased Smad7 expression. These results suggest that MPA may ameliorate CsA-induced FBN production by modulating the Smad signaling pathway. This study provides evidence that MPA can attenuate CsA-induced renal injury after kidney transplantation. copyright (C) 2012 S. Karger AG, Basel
URI
https://www.karger.com/Article/Abstract/343764http://repository.hanyang.ac.kr/handle/20.500.11754/69813
ISSN
0031-7012
DOI
10.1159/000343764
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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