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Study of highly selective and sensitive microarray structure based on hydrophilic/hydrophobic SAMS

Title
Study of highly selective and sensitive microarray structure based on hydrophilic/hydrophobic SAMS
Other Titles
hydrophobic SAMS
Author
박진구
Keywords
Fluorescence Analysis; Microarray; Self-Assembled Monolayer (SAM)
Issue Date
2013-01
Publisher
Scitec Publications Ltd
Citation
Solid State Phenomena, 2013, 195, P.82-85
Abstract
A microarray-based immunoassay requires only small volume of the sample in each array spot, which leads to faster completion of the immunoreactions than with an ELISA (enzyme-linked immunosorbent assay) [. However, this method still has some technical limitations such as poor signal sensitivity, poor detection limit, large sample consumption, high evaporation rate, coffee stain effect, low signal/noise ratio (SNR) and poor quality images. Recently, SAM (Self-Assembled Monolayer) method was extensively researched for control the surface wettability [. Especially, hydrophobic SAM functionalizations which has low surface energy are possible to prevent sample evaporation [ and to achieve anti-biofouling on them. Therefore, an introduction of hydrophobic SAM would enhance the detection sensitivity on bio array chip [4]. In this work, we fabricated a highly selective and sensitive pre-patterned microarray structure by using MEMS (Micro-Electro-Mechanical-System) process and hydrophilic/hydrophobic SAMs with various precursors.
URI
https://www.scientific.net/SSP.195.82http://repository.hanyang.ac.kr/handle/20.500.11754/69740
ISSN
1012-0394
DOI
10.4028/www.scientific.net/SSP.195.82
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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