Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line

Title
Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line
Author
황승용
Keywords
Triazole; Fungicide; MicroRNA; Toxicity; Microarray; MESSENGER-RNA EXPRESSION; ANTIFUNGAL AGENTS; MOUSE-LIVER; CYTOCHROME-P450; TOXICITY; MICE; RAT; PROPICONAZOLE; CHARACTERIZE; MYCLOBUTANIL
Issue Date
2013-01
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Toxicology ,7 January 2013, 303, p.94-98
Abstract
MicroRNA (miRNA) plays an important role in various diseases and in cellular and molecular responses to toxicants. In the present study, we investigated differential expression of miRNAs in response to three triazole fungicides (myclobutanil, propiconazole, and triadimefon). The human hepatoma cell line (HepG2) was treated with the above triazoles for 3 h or 48 h. miRNA-based microarray experiments were carried out using the Agilent human miRNA v13 array. At early exposure (3 h), six miRNAs were differentially expressed and at late exposure (48 h), three miRNAs were significantly expressed. Overall, this study provides an array of potential biomarkers for the above triazole fungicides. Furthermore, these miRNAs induced by triazoles could be the foundation for the development of a miRNA-based toxic biomarker library that can predict environmental toxicity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0300483X12003873http://repository.hanyang.ac.kr/handle/20.500.11754/69624
ISSN
0300-483X
DOI
10.1016/j.tox.2012.11.004
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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