Clinical value of metabolic tumor volume by PET/CT in extranodal natural killer/T cell lymphoma
- Title
- Clinical value of metabolic tumor volume by PET/CT in extranodal natural killer/T cell lymphoma
- Other Titles
- CT in extranodal natural killer
- Author
- 송무곤
- Keywords
- Lymphoma; Positron emission tomography; Radiotherapy
- Issue Date
- 2013-01
- Publisher
- Elsevier
- Citation
- Leukemia Research, January 2013, 37(1), p.58-63
- Abstract
- This study investigated whether metabolic tumor volume (MTV) by PET/CT as indicator of extent of lymphoma burden would be a prognostic factor in stage IE/IIE extranodal natural killer/T cell lymphoma (ENKTCL). Eighty patients with stage IE/IIE ENKTCL in the upper aerodigestive tract underwent PET/CT at diagnosis were enrolled and 32 patients received upfront radiotherapy (RTx). MTV was measured on PET/CT images by the extranodal region above SUV, 2.5. Receiver operating curve analyses indicated that an MTV of 35.2 cm3 was the ideal cut-off to distinguish between low and high MTV groups. Clinical outcomes were compared according to several prognostic factors (age, stage, high performance status [PS], high International Prognostic Index, elevated lactate dehydrogenase [LDH], local tumor invasiveness [LTI], high MTV and up-front RT). High PS, elevated LDH, LTI, high MTV and upfront RT were associated with survivals. In multivariate analysis, high MTV (PFS, HR = 4.170, 95% CI = 1.714–10.147, p = 0.002; OS, HR = 4.102, 95% CI = 1.617–10.408, p = 0.003) and up-front RT (PFS, HR = 0.410, 95%CI = 0.178–0.946, p = 0.037; OS, HR = 0.365, 95% CI = 0.152–0.872, p = 0.023) were significant independent prognostic factors. Upfront RTx and extent of tumor burden, as measured by the MTV, had significant prognostic value in patients with ENKTCL.
- URI
- https://www.sciencedirect.com/science/article/pii/S0145212612003840https://repository.hanyang.ac.kr/handle/20.500.11754/69607
- ISSN
- 0145-2126
- DOI
- 10.1016/j.leukres.2012.09.011
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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