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Fabrication of Microgel-in-Liposome Particles with Improved Water Retention

Title
Fabrication of Microgel-in-Liposome Particles with Improved Water Retention
Author
김진웅
Keywords
REVERSE-PHASE EVAPORATION; STRATUM-CORNEUM LIPIDS; MEMBRANE; VESICLES; PERMEABILITY; LIPOBEADS; HYDROGELS; EPIDERMIS; DELIVERY; BEHAVIOR
Issue Date
2012-03
Publisher
Amer Chemical SOC
Citation
LANGMUIR, 2012, 28(9), P.4095-4101
Abstract
Corneocytes represents the main water reservoir of stratum comeum, and that ability intimately arises from their architecture and total composition. Here we describe a novel method for fabricating a microgel-in-liposome (M-i-L) structure consisting of a sodium hyaluronate microgel and a lipid membrane envelop in order to mimic comeocyte cell structures. The essence of our approach is to use a lecithin-based microemulsion with a very low interfacial tension between the water droplet and oil continuous phase. Using this emulsion enables us to stabilize a dispersion of microgel particles without phase separation or aggregation. The addition of excess water produced single-core or multicore microgel particles enveloped in a lipid layer. To demonstrate the applicability of this unique vesicle system, we encapsulated a high concentration of natural moisturizing factor (NMF) in the microgel core and investigated how the M-i-L structure affected the water retention in comparison with other control systems. We have observed that our M-i-L particles with the NMF in the core, which mimicked the comeocyte cell structure, showed an excellent ability to retain water in the system. This experimental result inspired us to investigate how comeocyte cells, which feature a lipid-enveloped hydrogel structure, provide such long-lasting hydration to the skin.
URI
https://pubs.acs.org/doi/10.1021/la2046349http://repository.hanyang.ac.kr/handle/20.500.11754/69489
ISSN
0743-7463
DOI
10.1021/la2046349
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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