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Clinicopathological Significance of CADM4 Expression and its Correlation with E-cadherin and Ki-67 in Colorectal Adenocarcinomas

Title
Clinicopathological Significance of CADM4 Expression and its Correlation with E-cadherin and Ki-67 in Colorectal Adenocarcinomas
Author
민경환
Keywords
Adenocarcinoma; diagnosis; mortality; Cadherins; metabolism; Cell Adhesion Molecules; Colorectal Neoplasms; Disease-Free Survival
Issue Date
2012-10
Publisher
BRITISH MEDICAL ASSOC
Citation
Journal of Clinical Pathology, October 2012, 65(10), p.902-906
Abstract
Aims Cell adhesion molecule 4 (CADM4) is a novel tumour suppressor. The purpose of this study was to investigate the correlation between its expression and the expression of E-cadherin and Ki-67 in colorectal adenocarcinomas, as well as its effect on patient survival.Methods We evaluated CADM4 expression in tissue microarrays of 513 colorectal adenocarcinomas by immunohistochemistry.Results CADM4 was highly expressed in 210 of the 513 colorectal adenocarcinomas; expression was reduced in 185 cases and absent in the remaining cases. Loss of CADM4 expression was correlated with larger tumour size (6.2±2.1 cm vs 5.3±2.0 cm, p<0.001), mucinous tumour type (61.5% vs 20.9%, p<0.001), lymph node metastasis (31.4% vs 20.9%, p=0.022), higher Dukes stage (25.5% vs 19.6%, p=0.044), poorer differentiation (38.5% vs 18.8%, p<0.001), absence of E-cadherin expression (28.5% vs 16.0%, p=0.007) and presence of Ki-67 expression (27.3% vs 12.3%, p<0.001). In univariable Cox regression analysis, absence of CADM4 expression was associated with poorer overall survival (HR 0.712; 95% CI 0.512 to 0.989, p=0.042) and disease-free survival (HR 0.732; 95% CI 0.546 to 0.981, p=0.037). In multivariate analysis with the Cox proportional hazards model, CADM4 expression was not an independent prognostic factor of overall survival (HR 0.726; 95% CI 0.516 to 1.021, p=0.066) and disease-free survival (HR 0.762; 95% CI 0.563 to 1.033, p=0.080).Conclusions Loss of CADM4 expression is relatively frequent in colorectal adenocarcinomas and may play an important role in cancer progression and patient survival.
URI
http://jcp.bmj.com/content/early/2012/06/19/jclinpath-2012-200730.shorthttp://repository.hanyang.ac.kr/handle/20.500.11754/69448
ISSN
0021-9746
DOI
10.1136/jclinpath-2012-200730
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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