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dc.contributor.author주재범-
dc.date.accessioned2018-04-19T05:33:32Z-
dc.date.available2018-04-19T05:33:32Z-
dc.date.issued2012-01-
dc.identifier.citationNANOSCALE, 2012, 4(1), p124-p129, 6p.en_US
dc.identifier.issn2040-3372-
dc.identifier.urihttp://pubs.rsc.org/en/content/articlehtml/2012/nr/c1nr11243k-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/69357-
dc.description.abstractWe report a highly sensitive optical imaging technology using surface-enhanced Raman scattering (SERS)-fluorescence dual modal nanoprobes (DMNPs). Fluorescence microscopy is a well-known imaging technique that shows specific protein distributions within cells. However, most currently available fluorescent organic dyes have relatively weak emission intensities and are rapidly photo-bleached. Thus more sensitive and stable probes are needed. In this work we develop DMNPs, which can be used for both SERS and fluorescence detection. SERS detection is a powerful technique that allows ultrasensitive chemical or biochemical analysis through unlimited multiplexing and single molecule sensitivity. Combining advantages of fluorescence and SERS allows these dual modal nanostructures to be used as powerful probes for novel biomedical imaging. In this work, the fabrication and characterization of the SERS-fluorescence DMNPs and application to biological imaging were investigated using markers CD24 and CD44, which are co-expressed in MDA-MB-231 breast cancer cells, as a model system. SERS imaging with DMNPs was found to be a powerful tool to determine the co-localization of CD24 and CD44 in the cell.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundationof Korea (grant numbers R11-2009-044-1002 andK20904000004-09A0500-00410).en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectENHANCED RAMAN-SCATTERINGen_US
dc.subjectSEMICONDUCTOR QUANTUM DOTSen_US
dc.subjectHOLLOW GOLD NANOSPHERESen_US
dc.subjectLIVE CELLSen_US
dc.subjectLIVING CELLSen_US
dc.subjectNANOPARTICLE AGGREGATIONen_US
dc.subjectBIOLOGICAL APPLICATIONSen_US
dc.subjectSILICA NANOPARTICLESen_US
dc.subjectSPECTROSCOPIC TAGSen_US
dc.subjectSINGLE-MOLECULEen_US
dc.titleFabrication of SERS-fluorescence dual modal nanoprobes and application to multiplex cancer cell imagingen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume4-
dc.identifier.doi10.1039/C1NR11243K-
dc.relation.page124-129-
dc.relation.journalNANOSCALE-
dc.contributor.googleauthorLee, S.-
dc.contributor.googleauthorChon, H.-
dc.contributor.googleauthorYoon, S. Y.-
dc.contributor.googleauthorLee, E.-
dc.contributor.googleauthorChang, S. I.-
dc.contributor.googleauthorLim, D.-
dc.contributor.googleauthorChoo, J.-
dc.relation.code2012221035-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidjbchoo-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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