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근치적 수술 후 재발한 1, 2 병기 비소세포폐암의 임상양상 및 조직학적 유형의 차이 비교

Title
근치적 수술 후 재발한 1, 2 병기 비소세포폐암의 임상양상 및 조직학적 유형의 차이 비교
Other Titles
Original Articles : Clinicopathologic Characteristics of Recurrence after Curative-intent Surgical Therapy of Non-small Cell Lung Cancer
Author
김태형
Keywords
Carcinoma; Non-Small-Cell Lung; Recurrence; Prognosis; Histology
Issue Date
2011-04
Publisher
대한결핵 및 호흡기학회
Citation
Tuberculosis and Respiratory Diseases, 2011, 70(4), pg. 330-337, 8 p.
Abstract
Background: The clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC) have been changing. Recently, Positron emission tomography-computed tomography (PET-CT) has usually been used for diagnosis, follow-up to treatment and surveillance of NSCLC. We studied the pattern of recurrence and prognosis in patients who underwent complete resection for NSCLC according to histologic subtype. Methods: All patients who underwent complete resection for pathological stage I or II NSCLC between January 2005 and June 2009 were identified and clinical records were reviewed retrospectively, especially the histologic subtype. Results: Recurrences were identified in 50 of 112 patients who had complete resection of an NSCLC. Sites of recurrence were locoregional in 15 (30%), locoregional and distant in 20 (40%), and distant in 15 (30%). Also, sites of recurrence were intra-thoracic in 29 (58%), extrathoracic and intra-thoracic recurrence in 15 (30%), and extrathoracic in 6 (12%). In locoregional recurrence, there was 37% recurrence for non-squamous cell carcinoma (non-SQC) and 25% for squamous cell carcinoma (SQC). In distant recurrence, there was 39% recurrence for non-SQC and 18% for SQC. Locoregional recurrence in the bronchial stump was more common in SQC than non-SQC (14% vs. 45%, p=0.025). Prognosis of recurrence was not influenced by histologic subtype and the recurrence-free survival curve showed that the non-SQC group did not differ from the SQC group according to stage. Conclusion: The prognosis for recurrence does not seem to be influenced by histologic types, but locoregional recurrence in the bronchial stump seems to be more common in SQC than non-SQC in completely resected stage I and II NSCLC.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2905227http://repository.hanyang.ac.kr/handle/20.500.11754/69346
ISSN
1738-3536
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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