3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid 의 histone deacetylase 5 인산화에 의한 항우울효과에 대한 연구

Title
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid 의 histone deacetylase 5 인산화에 의한 항우울효과에 대한 연구
Author
박민협
Advisor(s)
손현
Issue Date
2018-02
Publisher
한양대학교
Degree
Master
Abstract
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. Here, I showed that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. Consequently, BDNF protein levels increased rapidly with the administration of CPP. Behavioral experiments revealed that CPP induced an antidepressant-like response and substantiated that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, these results imply that CPP acts via HDAC5.
URI
http://www.dcollection.net/handler/hanyang/000000104763http://repository.hanyang.ac.kr/handle/20.500.11754/68790
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > BIOMEDICAL SCIENCE(의생명과학과) > Theses (Master)
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