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Synthesis, photophysical and photochemical properties of pH-responsive phthalocyanine derivatives for photodynamic therapy

Title
Synthesis, photophysical and photochemical properties of pH-responsive phthalocyanine derivatives for photodynamic therapy
Author
조중현
Alternative Author(s)
Cho, Joong Hyun
Advisor(s)
정재윤
Issue Date
2018-02
Publisher
한양대학교
Degree
Master
Abstract
Photodynamic therapy (PDT) is a non-surgical treatment using drug and laser to cure tumor cells. Photosensitizers are used as a drug and generate reactive oxygen species in tumor cells by laser irradiation. Concentration of drug in tumor cells can improve maximize therapeutic effect and side effects can be minimized by local laser irradiation. To make therapeutic effect, singlet oxygen generation is necessary and photosensitizer must be stable to prevent decomposition. Also it must not have toxicity before activation to avoid side effects for normal cells. Phthalocyanine is green-blue dye and it is used in many fields with various properties. It can absorb red-NIR light to generate singlet oxygen through the triplet state. Also its thermal and chemical stability is very high and toxicity is very low. These properties are suitable for photosensitizer for PDT. But it have low solubility because of the planner structure, and it is a weak point to use as an injection drug. In this study, water soluble phthalocyanine was synthesized by introducing numerous triethylene glycols at the outside of phthalocyanine. And two phthalocyanines were connected by long chain, to form self-aggregation, which contain ketal structure to make selective appearance by decomposition of ketal structure around cancer cells by pH. Synthesized material was identified with various analytical instruments and self-aggregation was confirmed by comparing with unconnected monomer. Reducing of self-aggregation in various pH conditions was observed by UV-vis and fluorescence spectroscopy. Also, singlet oxygen generation of before and after decomposition were compared and improvement of efficient was confirmed.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/68310http://hanyang.dcollection.net/common/orgView/200000432210
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > ORGANIC AND NANO ENGINEERING(유기나노공학과) > Theses (Master)
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