Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승백 | - |
dc.date.accessioned | 2018-04-18T00:05:58Z | - |
dc.date.available | 2018-04-18T00:05:58Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 6, Page. 26531-26538 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/srep26531 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/68048 | - |
dc.description.abstract | In microfluidic filtration systems, one of the leading obstacles to efficient, continuous operation is clogging of the filters. Here, we introduce a lateral flow microfluidic sieving (mu-sieving) technique to overcome clogging and to allow continuous operation of filter based microfluidic separation. A low frequency mechanical oscillation was added to the fluid flow, which made possible the release of aggregated unwanted polystyrene (PS) particles trapped between the larger target PS particles in the filter demonstrating continuous mu-sieving operation. We achieved collection of the target PS particles with 100% separation efficiency. Also, on average, more than 98% of the filtered target particles were retrieved after the filtration showing high retrieval rates. Since the oscillation was applied to the fluid but not to the microfluidic filter system, mechanical stresses to the system was minimized and no additional fabrication procedures were necessary. We also applied the mu-sieving technique to the separation of cancer cells (MDA-MB-231) from whole blood and showed that the fluidic oscillations prevented the filters from being blocked by the filtered cancer cells allowing continuous microfluidic separation with high efficiency. | en_US |
dc.description.sponsorship | This research was supported by the Converging Research Center Program funded by the Ministry of Science, ICT & Future Planning (Project No. 2015054348), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A2011532 & 2012R1A6A1029029). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | CIRCULATING TUMOR-CELLS | en_US |
dc.subject | CONTINUOUS-FLOW | en_US |
dc.subject | PARTICLE SEPARATION | en_US |
dc.subject | RAPID ISOLATION | en_US |
dc.subject | SHEAR-STRESS | en_US |
dc.subject | CHIP DEVICE | en_US |
dc.subject | MICROFILTRATION | en_US |
dc.subject | CANCER | en_US |
dc.subject | FRACTIONATION | en_US |
dc.subject | MICROCHANNEL | en_US |
dc.title | Clogging-free microfluidics for continuous size-based separation of microparticles | en_US |
dc.type | Article | en_US |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.1038/srep26531 | - |
dc.relation.page | 26531-26538 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Yoon, Yousang | - |
dc.contributor.googleauthor | Kim, Seonil | - |
dc.contributor.googleauthor | Lee, Jusin | - |
dc.contributor.googleauthor | Choi, Jaewoong | - |
dc.contributor.googleauthor | Kim, Rae-Kwon | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | Sul, Onejae | - |
dc.contributor.googleauthor | Lee, Seung-Beck | - |
dc.relation.code | 2016012537 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF ELECTRONIC ENGINEERING | - |
dc.identifier.pid | sbl22 | - |
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