23 6

Clogging-free microfluidics for continuous size-based separation of microparticles

Title
Clogging-free microfluidics for continuous size-based separation of microparticles
Author
이승백
Keywords
CIRCULATING TUMOR-CELLS; CONTINUOUS-FLOW; PARTICLE SEPARATION; RAPID ISOLATION; SHEAR-STRESS; CHIP DEVICE; MICROFILTRATION; CANCER; FRACTIONATION; MICROCHANNEL
Issue Date
2016-05
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 6, Page. 26531-26538
Abstract
In microfluidic filtration systems, one of the leading obstacles to efficient, continuous operation is clogging of the filters. Here, we introduce a lateral flow microfluidic sieving (mu-sieving) technique to overcome clogging and to allow continuous operation of filter based microfluidic separation. A low frequency mechanical oscillation was added to the fluid flow, which made possible the release of aggregated unwanted polystyrene (PS) particles trapped between the larger target PS particles in the filter demonstrating continuous mu-sieving operation. We achieved collection of the target PS particles with 100% separation efficiency. Also, on average, more than 98% of the filtered target particles were retrieved after the filtration showing high retrieval rates. Since the oscillation was applied to the fluid but not to the microfluidic filter system, mechanical stresses to the system was minimized and no additional fabrication procedures were necessary. We also applied the mu-sieving technique to the separation of cancer cells (MDA-MB-231) from whole blood and showed that the fluidic oscillations prevented the filters from being blocked by the filtered cancer cells allowing continuous microfluidic separation with high efficiency.
URI
https://www.nature.com/articles/srep26531http://hdl.handle.net/20.500.11754/68048
ISSN
2045-2322
DOI
10.1038/srep26531
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRONIC ENGINEERING(융합전자공학부) > Articles
Files in This Item:
Clogging-free microfluidics for continuous size-based separation of microparticles.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE