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dc.contributor.author최한곤-
dc.date.accessioned2018-04-17T07:48:56Z-
dc.date.available2018-04-17T07:48:56Z-
dc.date.issued2016-08-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 147, Page. 250-257en_US
dc.identifier.issn0927-7765-
dc.identifier.issn1873-4367-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776516305872-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/68042-
dc.description.abstractThe aim of this study was to assess the effect of n-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) on the physicochemical characterization and oral bioavailability of a novel L-sulpiride-loaded quaternary microcapsule (QMC). The effect of carriers on drug solubility was investigated. Among the carriers tested, polyvinyl pyrrolidone (PVP), sodium lauryl sulphate (SLS) and TPGS were selected as polymer, surfactant and absorption enhancer, respectively, due to their high drug solubility. Using the solvent evaporation method, numerous QMCs with different ratios of L-sulpiride, PVP, SLS and TPGS were prepared, and their physicochemical properties, solubility and release were evaluated. In addition, the influence of TPGS concentration on the oral bioavailability of various drug doses was evaluated. All QMCs converted the crystalline drug to the amorphous form and remarkably improved the solubility, release and oral bioavailability of the drug. Furthermore, the TPGS concentration in the QMCs hardly affected the crystallinity, particle size and release, but considerably increased the solubility and oral bioavailability of the drug. In particular, as the dose of administered drug was increased, TPGS provided a greater improvement in oral drug bioavailability. Thus, TPGS played an important role in improving the oral bioavailability of L-sulpiride. Moreover, the QMC with a drug/PVP/SLS/TPGS weight ratio of 5:12:1 :20 with approximately 3.3-fold improved oral bioavailability would be recommended as a commercial pharmaceutical product for oral administration of L-sulpiride. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by National Research Foundation (NRF) of South Korea grants funded by the South Korea government (MEST) (Nos. 2015R1A2A2A05027872 & 2015R1A2A2A01004118) and a grant (16173MFDS542) from Ministry of Food and Drug Safety in 2016.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectL-sulpirideen_US
dc.subjectQuaternary microcapsuleen_US
dc.subjectD-alpha-tocopheryl polyethylene glycol 1000en_US
dc.subjectsuccinateen_US
dc.subjectOral absorptionen_US
dc.subjectAdministered drug doseen_US
dc.subjectIN-VIVO EVALUATIONen_US
dc.subjectBIOPHARMACEUTICS CLASSIFICATION-SYSTEMen_US
dc.subjectDRUG-DELIVERY SYSTEMen_US
dc.subjectVITAMIN-E TPGSen_US
dc.subjectSOLID LIPID NANOPARTICLESen_US
dc.subjectINTESTINAL-ABSORPTIONen_US
dc.subjectAQUEOUS SOLUBILITYen_US
dc.subjectPARTICLE-SIZEen_US
dc.subjectSOLUBLE DRUGen_US
dc.subjectMODEL-DRUGen_US
dc.titleDevelopment of a novel L-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailabilityen_US
dc.typeArticleen_US
dc.relation.volume147-
dc.identifier.doi10.1016/j.colsurfb.2016.08.010-
dc.relation.page250-257-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorKim, DS-
dc.contributor.googleauthorKim, DW-
dc.contributor.googleauthorKim, KS-
dc.contributor.googleauthorChoi, JS-
dc.contributor.googleauthorSeo, YG-
dc.contributor.googleauthorYoun, YS-
dc.contributor.googleauthorOh, KT-
dc.contributor.googleauthorYong, CS-
dc.contributor.googleauthorKim, JO-
dc.contributor.googleauthorChoi, HG-
dc.contributor.googleauthorJin, SG-
dc.relation.code2016001589-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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