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Novel piroxicam-loaded nanospheres generated by the electrospraying technique: physicochemical characterisation and oral bioavailability evaluation

Title
Novel piroxicam-loaded nanospheres generated by the electrospraying technique: physicochemical characterisation and oral bioavailability evaluation
Author
최한곤
Keywords
Piroxicam; nanospheres; electrospraying technique; solubility; oral bioavailability; IN-VIVO EVALUATION; SOLID DISPERSION; ELECTROHYDRODYNAMIC ATOMIZATION; CLOPIDOGREL NAPADISILATE; CLASSIFICATION-SYSTEM; DRUG; PARTICLES; NANOPARTICLES; SOLUBILITY; DELIVERY
Issue Date
2016-08
Publisher
TAYLOR & FRANCIS LTD
Citation
JOURNAL OF MICROENCAPSULATION, v. 33, No. 4, Page. 323-330
Abstract
To determine if a novel electrospraying technique could be applied to an oral drug delivery system for improving the solubility and oral bioavailability of poorly water-soluble piroxicam; the nanospheres were generated with drug and polyvinylpyrrolidone (PVP) using electrospraying technique; and their physicochemical properties, solubility, release and pharmacokinetics were evaluated in comparison with piroxicam powder. All nanospheres had significantly increased drug solubility and dissolution rates in comparison with the drug powder. In particular, the nanosphere composed of piroxicam and PVP at a weight ratio of 2:8 gave about 600-fold higher solubility, 15-fold higher release rate and 3-fold higher AUC in comparison to piroxicam powder, leading to significantly enhanced oral bioavailability in rats, due to the mingled effect of nanonisation along with transformation to the amorphous state. Thus, this electrospraying technique can be utilised to produce a novel oral nanosphere delivery system with enhanced solubility and oral bioavailability for poorly water-soluble piroxicam.
URI
https://www.tandfonline.com/doi/abs/10.1080/02652048.2016.1185475http://hdl.handle.net/20.500.11754/68026
ISSN
0265-2048; 1464-5246
DOI
10.1080/02652048.2016.1185475
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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