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Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila

Title
Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila
Author
심지원
Keywords
haemocyte; haematopoietic niche; FoxO; ROS; Spitz
Issue Date
2012-01
Publisher
Embo Press
Citation
EMBO REPORTS, VOl.13, No.1 [2012], p83-p89
Abstract
Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.
URI
http://embor.embopress.org/content/13/1/83http://hdl.handle.net/20.500.11754/67933
ISSN
1469-221X
DOI
10.1038/embor.2011.223
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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