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Dendrimer type bio-reducible polymer for efficient gene delivery

Title
Dendrimer type bio-reducible polymer for efficient gene delivery
Author
이민형
Keywords
Bioreducible polymer; Dendrimer; Gene delivery; Transfection; Cytotoxicity
Issue Date
2012-06
Publisher
Elsevier Science B.V
Citation
Journal of Controlled Release, 2012, 160(3), P.592-600
Abstract
Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP. The newly synthesized PAM-ABP was studied to determine its efficacy as a gene delivery carrier. The PAM-ABP demonstrated superior condensing ability for plasmid DNA through the formation of compact nanosized polyplexes. These compact polyplexes enhanced cellular uptake and were less susceptible to reducing agents, resulting in greater transfection efficiency compared to ABP alone. Based on these results, this newly developed PAM-ABP polyplex is a promising delivery system for clinical gene therapy. (C) 2012 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0168365912002660?via%3Dihubhttp://hdl.handle.net/20.500.11754/67859
ISSN
0168-3659
DOI
10.1016/j.jconrel.2012.04.025
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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