Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민형 | - |
dc.date.accessioned | 2018-04-16T04:01:36Z | - |
dc.date.available | 2018-04-16T04:01:36Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | Biomaterials, Vol.33, No.1 [2012], p207-217 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0142961211010647 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67737 | - |
dc.description.abstract | MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics probe in a single system using an AS1411 aptamer - and miRNA-221 molecular beacon (miR-221 MB)-conjugated magnetic fluorescence (MF) nanoparticle (MFAS miR-221 MB) to simultaneously target to cancer tissue, image intracellularly expressed miRNA-221 and treat miRNA-221-involved carcinogenesis. AS1411 aptamer-conjugated MF (MFAS) nanoparticles displayed a great selectivity and delivery into various cancer cell lines. The miR-221 MB detached from the MFAS miR-221 MB in the cytoplasm of C6 cells clearly imaged miRNA-221 biogenesis and simultaneously resulted in antitumor therapeutic effects by inhibiting miRNA function, indicating a successful astrocytoma-targeting theragnostics. MFAS miRNA MB can be easily applied to other cancers by simply changing a targeted miRNA highly expressed in cancers. | en_US |
dc.description.sponsorship | This work was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A085136), the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2011-0019270) and National Research Foundation of Korea (No. 2011-0027482). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | Aptamer | en_US |
dc.subject | micro RNA-221 | en_US |
dc.subject | Theragnostics | en_US |
dc.subject | Molecular beacon | en_US |
dc.subject | Multimodal nanoparticles | en_US |
dc.subject | Cancer targeting | en_US |
dc.title | Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.09.023 | - |
dc.relation.page | 207-217 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Kim, J. K. | - |
dc.contributor.googleauthor | Choi, K. J. | - |
dc.contributor.googleauthor | Lee, M. | - |
dc.contributor.googleauthor | Jo, M. h. | - |
dc.contributor.googleauthor | Kim, S. | - |
dc.relation.code | 2012201314 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | minhyung | - |
dc.identifier.researcherID | 7409120793 | - |
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