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Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals

Title
Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals
Author
고성호
Keywords
Coenzyme Q10; Hypoxia; Neural stem cells; Neuroprotection
Issue Date
2012-10
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Brain Research, 10 October 2012, 1478, p.64-73
Abstract
Recanalization and secondary prevention are the main therapeutic strategies for acute ischemic stroke. Neuroprotective therapies have also been investigated despite unsuccessful clinical results. Coenzyme Q10 (CoQ10), which is an essential cofactor for electron transport in mitochondria, is known to have an antioxidant effect. We investigated the protective effects of CoQ10 against hypoxia in neural stem cells (NSCs). We measured cell viability and levels of intracellular signaling proteins after treatment with several concentrations of CoQ10 under hypoxia-reperfusion. CoQ10 protected NSCs against hypoxia-reperfusion in a concentration-dependent manner by reducing growth inhibition and inhibiting free radical formation. It increased the expression of a number of survival-related proteins such as phosphorylated Akt (pAkt), phosphorylated glycogen synthase kinase 3-β (pGSK3-β), and B-cell lymphoma 2 (Bcl-2) in NSCs injured by hypoxia-reperfusion and reduced the expression of death-related proteins such as cleaved caspase-3. We conclude that CoQ10 has effects against hypoxia-reperfusion induced damage to NSCs by enhancing survival signals and decreasing death signals.
URI
https://www.sciencedirect.com/science/article/pii/S0006899312013583http://hdl.handle.net/20.500.11754/67680
ISSN
0006-8993
DOI
10.1016/j.brainres.2012.08.025
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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