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Effect of Spirulina maxima on spermatogenesis and steroidogenesis in streptozotocin-induced type I diabetic male rats

Title
Effect of Spirulina maxima on spermatogenesis and steroidogenesis in streptozotocin-induced type I diabetic male rats
Author
계명찬
Keywords
Spirulina maxima; Spermatogenesis; Steroidogenesis; Diabetic rats
Issue Date
2012-01
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Food Chemistry, VOl.134, No.1 [2012], p173-179
Abstract
Spirulina maxima is a blue–green alga widely used for therapeutic and health supplements and foods. This study aimed to investigate the effect of S. maxima extracts (SME) on the spermatogenesis and steroidogenesis in streptozotocin (STZ)-induced diabetic rat testes. Adult male rats were divided into control, SME (200 mg/kg bw/day, 4 weeks), STZ (single injection of 50 mg/kg bw), STZ + SME (SME 200 mg/kg bw/day, 4 weeks after STZ 50 mg/kg bw), SME + STZ (STZ 50 mg/kg bw after SME 200 mg/kg bw/day for 2 weeks) and water + STZ (STZ 50 mg/kg bw after water feeding for 2 weeks) groups. SME intake for 4 weeks significantly increased the body and testis weights, metabolic parameters, normal seminiferous tubules, Leydig cell number, testosterone levels and steroidogenic enzymes mRNA in the STZ treated rat. SME intake for 2 weeks before STZ injection also mitigated diabetic testis dysfunction. SME might have a protective effect on diabetic rat testis.
URI
http://www.sciencedirect.com/science/article/pii/S0308814612002737?via%3Dihubhttp://hdl.handle.net/20.500.11754/67536
ISSN
0308-8146
DOI
10.1016/j.foodchem.2012.02.085
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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