Tocopheryl acetate nanoemulsions stabilized with lipid-polymer hybrid emulsifiers for effective skin delivery
- Title
- Tocopheryl acetate nanoemulsions stabilized with lipid-polymer hybrid emulsifiers for effective skin delivery
- Author
- 김진웅
- Keywords
- Nanoemulsions; Biodegradable polymers; Polymeric emulsifiers; Phospholipids; Skin drug delivery
- Issue Date
- 2012-06
- Publisher
- Elsevier Science B.V
- Citation
- Colloids and Surfaces B-Biointerfaces, 2012, 94, P.51-57
- Abstract
- Tocopheryl acetate is used as the oil component of nanoemulsions using a mixture of unsaturated phospholipids and polyethylene oxide-block-poly(epsilon-caprolactone) (PEO-b-PCL). This study investigates the effects of the lipid-polymer composition on the size and surface charge of nanoemulsions, microviscosity of the interfacial layer, and skin absorption of tocopheryl acetate. The lipid-polymer hybrid system exhibits excellent colloidal dispersion stability, which is comparable to that of polymer-based nanoemulsions. If lipids are used as emulsifiers, nanoemulsions show poor dispersion stability despite a good skin absorption enhancing effect. The amount of tocopheryl acetate absorbed by the skin increases with an increased lipid-to-polymer ratio, as determined using the hairless guinea pig skin loaded in a Franz-type diffusion cell. An 8:2 (w/w) mixture of unsaturated phospholipids and PEO-b-PCL exhibits the most efficient delivery of tocopheryl acetate into the skin. Our results show that tocopheryl acetate is absorbed almost twice as fast by the lipid-polymer hybrid system than the nanoemulsions stabilized with PEO-b-PCL. This study suggests that the lipid-polymer hybrid system can be used as an effective means of optimizing nanoemulsions in terms of dispersion stability and skin delivery capability. (C) 2012 Elsevier B.V. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0927776512000410?via%3Dihubhttp://hdl.handle.net/20.500.11754/67515
- ISSN
- 0927-7765
- DOI
- 10.1016/j.colsurfb.2012.01.016
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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