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dc.contributor.author김진웅-
dc.date.accessioned2018-04-16T02:21:58Z-
dc.date.available2018-04-16T02:21:58Z-
dc.date.issued2012-06-
dc.identifier.citationElsevier Science B.Ven_US
dc.identifier.issn2236-1356-
dc.identifier.issn0927-7765-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776512000744?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/67499-
dc.description.abstractThe recovery of skin barrier functions was investigated with pseudo-ceramide-based lipid microparticles. The microparticles were prepared by using a fluid bed technique where lipid components (a pseudo-ceramide, cholesterol and a fatty acid) were coated on a sugar seed, and a polymer was subsequently coated on the lipid microparticles. The microparticles contained large amount of pseudo-ceramide, and the pseudo-ceramide was in the form of lamellar structures mixed with other lipid components. In addition, the microparticles were stably dispersed in aqueous media or emulsion systems without any disruption of the microparticles' structures, thereby supplying sufficient amount of the pseudoceramide to skins for improving skin barrier functions such as preventing water loss. Such a role of the microparticles was proven by evaluating in vivo the efficacy of the lipid microparticles in reducing a trans-epidermal water loss (TEWL) of impaired murine skins. As a result, the novel pseudo-ceramide-based lipid microparticles for barrier recovery may potentially be applied in the field of dermatology, cosmetics and pharmaceuticals. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by BK 21 program at Hanyang University and a Manpower Development Program for Energy (the Ministry of Knowledge and Economy, MKE).en_US
dc.language.isoenen_US
dc.publisherElsevier Science B.Ven_US
dc.subjectLipid microparticleen_US
dc.subjectPseudo-ceramideen_US
dc.subjectLamellar structuresen_US
dc.subjectImproved skin barrier functionen_US
dc.titleFabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier functionen_US
dc.typeArticleen_US
dc.relation.volume94-
dc.identifier.doi10.1016/j.colsurfb.2012.01.049-
dc.relation.page236-241-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorKim, D. H.-
dc.contributor.googleauthorPark, W. R.-
dc.contributor.googleauthorKim, J. H.-
dc.contributor.googleauthorCho, E. C.-
dc.contributor.googleauthorAn, E. J.-
dc.contributor.googleauthorKim, J. W.-
dc.contributor.googleauthorOh, S. G.-
dc.relation.code2012212663-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidkjwoong-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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