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Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function

Title
Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function
Author
김진웅
Keywords
Lipid microparticle; Pseudo-ceramide; Lamellar structures; Improved skin barrier function
Issue Date
2012-06
Publisher
Elsevier Science B.V
Citation
Elsevier Science B.V
Abstract
The recovery of skin barrier functions was investigated with pseudo-ceramide-based lipid microparticles. The microparticles were prepared by using a fluid bed technique where lipid components (a pseudo-ceramide, cholesterol and a fatty acid) were coated on a sugar seed, and a polymer was subsequently coated on the lipid microparticles. The microparticles contained large amount of pseudo-ceramide, and the pseudo-ceramide was in the form of lamellar structures mixed with other lipid components. In addition, the microparticles were stably dispersed in aqueous media or emulsion systems without any disruption of the microparticles' structures, thereby supplying sufficient amount of the pseudoceramide to skins for improving skin barrier functions such as preventing water loss. Such a role of the microparticles was proven by evaluating in vivo the efficacy of the lipid microparticles in reducing a trans-epidermal water loss (TEWL) of impaired murine skins. As a result, the novel pseudo-ceramide-based lipid microparticles for barrier recovery may potentially be applied in the field of dermatology, cosmetics and pharmaceuticals. (C) 2012 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0927776512000744?via%3Dihubhttp://hdl.handle.net/20.500.11754/67499
ISSN
2236-1356; 0927-7765
DOI
10.1016/j.colsurfb.2012.01.049
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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