Small interfering RNAsi; RNA delivery; cationic peptide; liposome; targeted delivery
Issue Date
2012-02
Publisher
ACADEMIC PRESS INC LTD
Citation
Methods in Enzymology, 2012, 502, P.91-122
Abstract
Cellular targeting and intracellular delivery of small interfering RNA (siRNA) remain a critical barrier to the clinical application of RNA interference. This chapter provides an overview of various delivery agents employing protein ligands mediating cell-specific delivery of siRNA. Specifically, the chapter details methodologies for the conjugation of antibody or peptide ligands to i) the cationic peptide-oligo-9-arginine (ii) the polymer poly(lactic-co-glycolic acid) (PLGA) and (iii) a lipid-vesicle (liposome).