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Diagnostic and prognostic relevance of Cullin1 expression in invasive ductal carcinoma of the breast

Title
Diagnostic and prognostic relevance of Cullin1 expression in invasive ductal carcinoma of the breast
Author
민경환
Keywords
Progesterone; Survival Analysis; Tissue Array Analysis; Tumor Suppressor Protein p53
Issue Date
2012-10
Publisher
BRITISH MEDICAL ASSOC
Citation
Journal of Clinical Pathology, Oct 01, 2012, 65(10), p.896-901
Abstract
Background Cullin1 (Cul1) is a matrix degrading enzyme known to be involved in the remodelling of extracellular matrix proteins. This enzyme has recently been reported to play a key role in tumour progression and its presence is associated with poor clinical outcome for several different types of tumours.Methods 159 patients diagnosed with invasive ductal carcinoma between 2000 and 2005 were studied. Cul1 expression was analysed by immunohistochemical staining on a tissue microarray. The relationship between Cul1 expression and clinicopathological parameters was evaluated.Results Tumour expression of Cul1 was correlated with prognostic factors such as high histological grade and p53 expression, and was also linked to negative ER and positive HER2 as therapeutic markers (all p<0.05). There was a significant association between poor overall survival and high Cul1 expression in both univariate and multivariate analyses (all p<0.05).Conclusions Cul1 expression was significantly associated with high-grade tumours and poor prognosis, suggesting that it may play a role in breast tumour progression. Cul1 expression may therefore be crucial for the prediction of disease outcome in breast cancer patients.
URI
http://jcp.bmj.com/content/early/2012/07/13/jclinpath-2012-200847.fullhttp://hdl.handle.net/20.500.11754/67394
ISSN
0021-9746
DOI
10.1136/jclinpath-2012-200847
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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