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A Case of Acute Hepatitis B by Occult HBV Infection without HbsAg Seroconversion

Title
A Case of Acute Hepatitis B by Occult HBV Infection without HbsAg Seroconversion
Other Titles
잠재감염에 의한 HBsAg 음성 B형 간염 급성 악화 1예
Author
전대원
Keywords
Hepatitis B Surface Antigens; Hepatitis B; Rituximab
Issue Date
2012-10
Publisher
대한내과학회
Citation
Korean Journal of Medicine, 2012, 83(5), pg. 619-623, 5 p.
Abstract
Many studies have recently reported reactivation in hepatitis B surface antigen (HBsAg)-negative subjects with the use of biologic agents such as rituximab. However, occult hepatitis B virus infection itself has little clinical impact. We experienced a case of acute exacerbation caused by occult hepatitis B infection without HBsAg seroconversion. No mutation was found on the major hydrophilic loop of the S protein. The patient recovered from acute exacerbation after antiviral therapy. In conclusion, acute exacerbation can be induced by occult hepatitis B virus infection itself without reactivation. In such a case, antiviral therapy should be considered. (Korean J Med 2012;83:619-623)
URI
https://www.e-sciencecentral.org/articles/?scid=SC000008836http://hdl.handle.net/20.500.11754/67385
ISSN
1738-9364
DOI
10.3904/kjm.2012.83.5.619
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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