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Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway

Title
Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway
Author
고성호
Keywords
Amyloid-β; Coenzyme Q10; Oxidative stress; Neuroprotection; Phosphatidylinositol 3-kinase
Issue Date
2012-01
Publisher
Elsevier Science B.V., Amsterdam.
Citation
NeuroToxicology, Vol.33, No.1 [2012], p85-90
Abstract
Oxidative stress plays critical roles in the pathogenic mechanisms of several neurodegenerative disorders including Alzheimer's disease (AD), thus much research effort has focused on antioxidants as potential treatment agents for AD. Coenzyme Q10 (CoQ10) is known to have powerful antioxidant effects. We investigated the neuroprotective effects of CoQ10 against Amyloid beta25–35 (Aβ25–35)-induced neurotoxicity in rat cortical neurons. To evaluate the neuroprotective effects of CoQ10 on Aβ25–35-injured neurons, primary cultured cortical neurons were treated with several concentrations of CoQ10 and/or Aβ25–35 for 48h. CoQ10 protected neuronal cells against Aβ25–35-induced neurotoxicity in a concentration
URI
http://www.sciencedirect.com/science/article/pii/S0161813X11002142?via%3Dihubhttp://hdl.handle.net/20.500.11754/67152
ISSN
0161-813X
DOI
10.1016/j.neuro.2011.12.005
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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