Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-04-15T15:19:37Z | - |
dc.date.available | 2018-04-15T15:19:37Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | CELL RESEARCH, Vol.22, No.5 [2012], p873-p885 | en_US |
dc.identifier.issn | 1001-0602 | - |
dc.identifier.uri | https://www.nature.com/articles/cr201238 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67040 | - |
dc.description.abstract | The serine/threonine kinase Akt functions in multiple cellular processes, including cell survival and tumor development. Studies of the mechanisms that negatively regulate Akt have focused on dephosphorylation-mediated inactivation. In this study, we identified a negative regulator of Akt, MULAN, which possesses both a RING finger domain and E3 ubiquitin ligase activity. Akt was found to directly interact with MULAN and to be ubiquitinated by MULAN in vitro and in vivo. Other molecular assays demonstrated that phosphorylated Akt is a substantive target for both interaction with MULAN and ubiquitination by MULAN. The results of the functional studies suggest that the degradation of Akt by MULAN suppresses cell proliferation and viability. These data provide insight into the Akt ubiquitination signaling network. | en_US |
dc.description.sponsorship | We would like to thank Dr Dirk Bohmann (University of Rochester, USA) for kindly providing the HA-Ub plasmid and Dr Zhijian Chen (University of Texas Southwestern Medical Center, USA) for the HA-Ub-K48R and HA-Ub-K63R mutant constructs. This work was supported by grants from the Ministry of Education, Science and Technology (grants 20110028646 to S An and 20100018768 to J H Lee), the National R&D Program for Cancer Control, the Ministry of Health & Welfare (0720070 to S An), and the Korea Foundation for Cancer Research (KFCR-2009-002 to S Bae) of the Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.subject | ubiquitin E3 ligase | en_US |
dc.subject | inhibition | en_US |
dc.subject | growth regulation | en_US |
dc.title | Akt is negatively regulated by the MULAN E3 ligase | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 22 | - |
dc.identifier.doi | 10.1038/cr.2012.38 | - |
dc.relation.page | 873-885 | - |
dc.relation.journal | CELL RESEARCH | - |
dc.contributor.googleauthor | Bae, S. | - |
dc.contributor.googleauthor | Kim, S. Y. | - |
dc.contributor.googleauthor | Jung, J. H. | - |
dc.contributor.googleauthor | Yoon, Y. | - |
dc.contributor.googleauthor | Cha, H. J. | - |
dc.contributor.googleauthor | Lee, H. | - |
dc.contributor.googleauthor | Kim, K. | - |
dc.contributor.googleauthor | Kim, J. | - |
dc.contributor.googleauthor | An, I. S. | - |
dc.contributor.googleauthor | Kim, J. | - |
dc.relation.code | 2012212651 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
dc.identifier.researcherID | 8066538700 | - |
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