Akt is negatively regulated by the MULAN E3 ligase

Title
Akt is negatively regulated by the MULAN E3 ligase
Author
이수재
Keywords
ubiquitin E3 ligase; inhibition; growth regulation
Issue Date
2012-05
Publisher
Nature Publishing Group
Citation
CELL RESEARCH, Vol.22, No.5 [2012], p873-p885
Abstract
The serine/threonine kinase Akt functions in multiple cellular processes, including cell survival and tumor development. Studies of the mechanisms that negatively regulate Akt have focused on dephosphorylation-mediated inactivation. In this study, we identified a negative regulator of Akt, MULAN, which possesses both a RING finger domain and E3 ubiquitin ligase activity. Akt was found to directly interact with MULAN and to be ubiquitinated by MULAN in vitro and in vivo. Other molecular assays demonstrated that phosphorylated Akt is a substantive target for both interaction with MULAN and ubiquitination by MULAN. The results of the functional studies suggest that the degradation of Akt by MULAN suppresses cell proliferation and viability. These data provide insight into the Akt ubiquitination signaling network.
URI
https://www.nature.com/articles/cr201238http://hdl.handle.net/20.500.11754/67040
ISSN
1001-0602
DOI
10.1038/cr.2012.38
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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