Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives

Title
Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives
Author
김진웅
Keywords
collagenase-1; triterpenoids; dihydroquercetin; photoageing; interleukin-8
Issue Date
2012-05
Publisher
Springer Science + Business Media
Citation
Russian Journal of Bioorganic Chemistry, Vol.38, No.3 [2012], p328–334
Abstract
Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).
URI
http://link.springer.com/article/10.1134/S1068162012030028http://hdl.handle.net/20.500.11754/67016
ISSN
1068-1620
DOI
10.1134/S1068162012030028
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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