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Recent trends in the treatment of chronic hepatitis C.

Title
Recent trends in the treatment of chronic hepatitis C.
Author
전대원
Keywords
Chronic hepatits C; Pegylated interferon; Ribavirin; Response-guided therapy
Issue Date
2012-05
Publisher
The Korean Association for the Study of the Liver, 2012.
Citation
The Korean journal of hepatology . v.18 no.1, 2012년, pp.22 - 28
Abstract
Pegylated interferon and ribavirin combination therapy is accepted as the standard antiviral treatment for chronic hepatitis C regardless of HCV genotype. This combination therapy achieves higher response rates than previous therapy, but, nevertheless, a large proportion of patients suffer from treatment failure or adverse events. Recent clinical studies of viral kinetics during antiviral treatment have led to the introduction of response-guided therapy, the concept of 'customized therapy depending on viral response', which focuses on modulation of the treatment period depending on the viral response to create a sustained viral response without unnecessary medication and costs. New upcoming direct-acting antivirals (DAAs) maximize response rate, and triple therapy including DAAs along with pegylated interferon and ribavirin combination therapy could soon be the standard therapy. In this article, we reviewed the factors affecting treatment, response guided treatment, retreatment after failure of standard treatment, management of adverse events during treatment, and new treatment options.
URI
https://www.e-cmh.org/journal/view.php?doi=10.3350/kjhep.2012.18.1.22http://hdl.handle.net/20.500.11754/66907
ISSN
1226-0479
DOI
10.3350/kjhep.2012.18.1.22
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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