Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet
- Title
- Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet
- Author
- 황승용
- Keywords
- Korean red ginseng extract; anti-obesity; microarray; high-fat diet
- Issue Date
- 2012-05
- Publisher
- WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
- Citation
- JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 권: 92, 호: 2, 페이지: 388-396
- Abstract
- BACKGROUND: Ginseng saponin and ginsenosides exert anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti-obesity effects of ginseng and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti-obesity effects of Korean red ginseng extract (KRGE) and hepatic gene expression profiles in mice fed long-term on a high-fat diet (HFD) in this study. RESULTS: KRGE reduces the levels of cholesterol, low- density lipoprotein- cholesterol (LDL- C), serum triglycerides, and atherogenic indices. Levels of leptin, adiponectin and insulin, which regulate glucose and lipid metabolism, were impaired profoundly by HFD. However, KRGE treatment brought these levels back to normal. KRGE was found to down- regulate genes associated with lipid metabolism or cholesterol metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up- regulated by HFD. CONCLUSION: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing obesity. (C) 2011 Society of Chemical Industry
- URI
- http://onlinelibrary.wiley.com/doi/10.1002/jsfa.4589/abstracthttp://hdl.handle.net/20.500.11754/66894
- ISSN
- 0022-5142
- DOI
- 10.1002/jsfa.4589
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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