Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet

Title
Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet
Author
황승용
Keywords
Korean red ginseng extract; anti-obesity; microarray; high-fat diet
Issue Date
2012-05
Publisher
WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Citation
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 권: 92, 호: 2, 페이지: 388-396
Abstract
BACKGROUND: Ginseng saponin and ginsenosides exert anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti-obesity effects of ginseng and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti-obesity effects of Korean red ginseng extract (KRGE) and hepatic gene expression profiles in mice fed long-term on a high-fat diet (HFD) in this study. RESULTS: KRGE reduces the levels of cholesterol, low- density lipoprotein- cholesterol (LDL- C), serum triglycerides, and atherogenic indices. Levels of leptin, adiponectin and insulin, which regulate glucose and lipid metabolism, were impaired profoundly by HFD. However, KRGE treatment brought these levels back to normal. KRGE was found to down- regulate genes associated with lipid metabolism or cholesterol metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up- regulated by HFD. CONCLUSION: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing obesity. (C) 2011 Society of Chemical Industry
URI
http://onlinelibrary.wiley.com/doi/10.1002/jsfa.4589/abstracthttp://hdl.handle.net/20.500.11754/66894
ISSN
0022-5142
DOI
10.1002/jsfa.4589
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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