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V2 Receptor Antagonist: Tolvaptan

Title
V2 Receptor Antagonist: Tolvaptan
Author
김호중
Keywords
tolvaptan; hyponatremia; arginine vasopressin receptors
Issue Date
2011-12
Publisher
The Korean Society of Electrolyte Metabolism
Citation
Electrolytes & Blood Pressure, 2011, 9(2), P.50-54, 5P.
Abstract
Hyponatremia is the most common electrolyte disorder in hospitalized patients. Many studies documented that it was related to increased morbidity and mortality in patients with congestive heart failure, liver cirrhosis, and neurologic diseases. Although knowledge of hyponatremia has been cumulated, the optimal management of hyponatremia remains incompletely established in clinical practice because of the diversity of underlying disease states, and its multiple causes with differing pathophysiologic mechanisms. Since vasopressin receptor antagonists have unique aquaretic effect to selectively increase electrolytes-free water excretion, clinicians could apply a more effective method to treat hyponatremia. Tolvaptan has significant evidence that it improves serum sodium levels in patients with euvolemic or hypervolemic hyponatremia related with heart failure, cirrhosis or syndrome of inappropriate anti-diuretic hormone. Tolvaptan has acceptable safety and tolerability for long-term usage in chronic hyponatremia, and the beneficial effects on serum Na+ occurred in patients with both mild and marked hyponatremia.
URI
https://synapse.koreamed.org/DOIx.php?id=10.5049/EBP.2011.9.2.50
ISSN
1738-5997
DOI
10.5049/EBP.2011.9.2.50
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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