Selective Trace Analysis of Mercury (II) Ions in Aqueous Media Using SERS-Based Aptamer Sensor

Title
Selective Trace Analysis of Mercury (II) Ions in Aqueous Media Using SERS-Based Aptamer Sensor
Author
주재범
Keywords
Silver nanoparticle; Surface-enhanced raman scattering; Mercury ion; Aptamer sensor
Issue Date
2011-06
Publisher
KOREAN CHEMICAL SOCIETY
Citation
BULLETIN- KOREAN CHEMICAL SOCIETY, 2011, 32(6), P.2003-2007
Abstract
We report a highly sensitive surface-enhanced Raman scattering (SERS) platform for the selective trace analysis of mercury (II) ions in drinkable water using aptamer-conjugated silver nanoparticles. Here, an aptamer designed to specifically bind to Hg^(2+) ions in aqueous solution was labelled with a TAMRA moiety at the 5' end and used as a Raman reporter. Polyamine spermine tetrahydrochloride (spermine) was used to promote surface adsorption of the aptamer probes onto the silver nanoparticles. When Hg^(2+) ions are added to the system, binding of Hg^(2+) with T-T pairs results in a conformational rearrangement of the aptamer to form a hairpin structure. As a result of the reduced of electrostatic repulsion between silver nanoparticles, aggregation of silver nanoparticles occurs, and the SERS signal is significantly increased upon the addition of Hg^(2+) ions.
URI
http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2011_v32n6_2003http://hdl.handle.net/20.500.11754/66654
ISSN
0253-2964
DOI
10.5012/bkcs.2011.32.6.2003
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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