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Clinicopathologic significance of serum response factor expression in colorectal adenocarcinomas

Title
Clinicopathologic significance of serum response factor expression in colorectal adenocarcinomas
Author
백승삼
Keywords
Extrapulmonary; Lymphangiomyoma; Mesentery
Issue Date
2011-06
Publisher
BLACKWELL PUBLISHING LTD
Citation
BASIC AND APPLIED PATHOLOGY, 2011, 4(2), P.46-52
Abstract
Background and aim: The purpose of this study was to investigate the role of serum response factor (SRF) expression and to evaluate its correlation with various clinicopathological parameters in colorectal adenocarcinomas. Methods: We used tissue microarrays consisting of 24 normal mucosa, 50 tubular adenomas, 496 adenocarcinomas, and 128 metastatic lesions. Results: The expression of SRF was rare in normal colonic mucosa with a mean expression score of 0.67 ± 0.17. Tubular adenomas had a mean expression score of 2.48 ± 0.31, adenocarcinomas 2.82 ± 0.13 and lymph node metastases 2.82 ± 0.36. Interestingly, SRF expression was high in distant metastases with a mean expression score of 4.83 ± 0.43. The mean SRF expression was increased significantly early in the normal‐adenoma‐carcinoma sequence and again in distant metastases. The positive SRF expression was strongly correlated with non‐mucinous tumor type (P < 0.001). Moderately and poorly differentiated adenocarcinomas had higher mean expression scores than well‐differentiated adenocarcinomas (2.88 ± 0.13 vs 1.33 ± 0.32) (P= 0.015). There were significant associations between SRF expression and expression of p53 (P= 0.034) and Ki‐67 (P= 0.001). Conclusions: Our results suggest that SRF expression may be the early event of normal‐adenoma‐carcinoma sequence of colorectal cancer, especially in adenomatous change of colonic mucosa and may play an important role in distant metastasis of colorectal cancers.
URI
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-9294.2011.01103.xhttp://hdl.handle.net/20.500.11754/66523
ISSN
1755-9294
DOI
10.1111/j.1755-9294.2011.01103.x
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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