Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-04-15T02:41:59Z | - |
dc.date.available | 2018-04-15T02:41:59Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | Inflammation research, 2012, 61(7), P.665-671 | en_US |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00011-012-0459-1 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/66418 | - |
dc.description.abstract | ObjectiveThe aim of this study was to determine whether the functional interleukin-6 (IL-6) promoter −174 G/C and −572 G/C polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.MethodsMeta-analysis was conducted on the associations between these IL-6 polymorphisms and RA.ResultsA total of nine studies involving 3,851 subjects (RA 2,053 and controls 1,798) were considered in this study and ethnicity-specific meta-analysis was performed on European subjects. In all study subjects, meta-analysis revealed a trend toward to an association between RA and the IL-6 −174 G allele (odds ratio [OR] = 0.699, 95 % confidence interval [CI] = 0.463–1.054, p = 0.088). Stratification by ethnicity indicated a significant association between RA and the IL-6 −174 G/C polymorphism in Europeans using the dominant (OR = 0.329, 95 % CI = 0.155–0.699, p = 0.004) and recessive (OR = 0.823, 95 % CI = 0.679–0.997, p = 0.047) models. Meta-analysis of the IL-6 −572 G/C polymorphism showed no association between RA and the IL-6 −572 G allele in all study subjects (OR = 1.641, 95 % CI = 0.613–4.397, p = 0.324).ConclusionsThis meta-analysis shows that the IL-6 −174 G/C polymorphism may confer susceptibility to RA in Europeans. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science + Business Media | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 61 | - |
dc.identifier.doi | 10.1007/s00011-012-0459-1 | - |
dc.relation.page | 665-671 | - |
dc.relation.journal | INFLAMMATION RESEARCH | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.contributor.googleauthor | Bae, S. C. | - |
dc.contributor.googleauthor | Choi, S. J. | - |
dc.contributor.googleauthor | Ji, J. D. | - |
dc.contributor.googleauthor | Song, G. G. | - |
dc.relation.code | 2012204016 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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