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dc.contributor.author박장환-
dc.date.accessioned2018-04-14T14:20:08Z-
dc.date.available2018-04-14T14:20:08Z-
dc.date.issued2012-07-
dc.identifier.citationThe European journal of neuroscience, 2012, 36(6), P.2743-2752en_US
dc.identifier.issn0953-816X-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1460-9568.2012.08192.x-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/66338-
dc.description.abstractNeural network activity regulates the development of hippocampal newborn granule cells (GCs). Excitatory GABAergic input is known to be a key player in this regulation. Although calcium signaling is thought to be a downstream mediator of GABA, GABA-induced calcium signaling in newborn GCs is not well understood. We investigated Ca2+ signaling and its regulatory role in axon and dendrite outgrowth in newborn GCs identified in the organotypic slice culture of early postnatal rat hippocampus. Here, we report that hippocampal network activity can induce calcium transients (CaTs) in newborn GCs during the first post-mitotic week via GABAergic inputs. The GABA-induced CaTs were mediated mainly by L-type Ca2+ channels. Furthermore, we found that inhibiting any step in the signaling pathway, network activity ? GABA ? L-type Ca2+ channels, selectively suppressed the axonal outgrowth and pruning of newborn GCs, but not dendritic outgrowth. The GABAA receptor blocker bicuculline significantly suppressed axonal outgrowth, despite increasing network activity, thus indicating an essential role of GABAergic inputs. Therefore, we conclude that network activity-dependent GABAergic inputs open L-type Ca2+ channels and promote axonal outgrowth in newborn GC during the first post-mitotic week.en_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subjectaxon outgrowthen_US
dc.subjectGABAen_US
dc.subjectgranule cellsen_US
dc.subjecthippocampusen_US
dc.subjectL‐type calcium channelen_US
dc.subjectpostnatal neurogenesisen_US
dc.titleGABA mediates the network activity-dependent facilitation of axonal outgrowth from the newborn granule cells in the early postnatal rat hippocampusen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/j.1460-9568.2012.08192.x-
dc.relation.page1-10-
dc.relation.journalEUROPEAN JOURNAL OF NEUROSCIENCE-
dc.contributor.googleauthorLee, H.-
dc.contributor.googleauthorLee, D.-
dc.contributor.googleauthorPark, C. H.-
dc.contributor.googleauthorHo, W. K.-
dc.contributor.googleauthorLee, S. H.-
dc.relation.code2012203035-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidchshpark-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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