Recent advances in microfluidic technologies for biochemistry and Molecular biology

Title
Recent advances in microfluidic technologies for biochemistry and Molecular biology
Author
주재범
Keywords
Biosensors; Emulsion PCR; Genomics; High throughput screening; Microfluidics; Protein-protein interaction; Proteomics
Issue Date
2011-11
Publisher
Korean Society for Biochemistry and Molecular Biology
Citation
BMB Reports, 2011, 44(11), P.705-712
Abstract
Advances in the fields of proteomics and genomics have necessitated the development of high-throughput screening methods (HTS) for the systematic transformation of large amounts of biological/chemical data into an organized database of knowledge. Microfluidic systems are ideally suited for high-throughput biochemical experimentation since they offer high analytical throughput, consume minute quantities of expensive biological reagents, exhibit superior sensitivity and functionality compared to traditional micro-array techniques and can be integrated within complex experimental work flows. A range of basic biochemical and molecular biological operations have been transferred to chip-based microfluidic formats over the last decade, including gene sequencing, emulsion PCR, immunoassays, electrophoresis, cell-based assays, expression cloning and macromolecule blotting. In this review, we highlight some of the recent advances in the application of microfluidics to biochemistry and molecular biology.
URI
http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2011_v44n11_705
ISSN
1976-6696
DOI
10.5483/BMBRep.2011.44.11.705
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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