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dc.contributor.author황세진-
dc.date.accessioned2018-04-14T11:18:54Z-
dc.date.available2018-04-14T11:18:54Z-
dc.date.issued2011-01-
dc.identifier.citationAntioxidants & redox signaling v.14 no.2,2011년, pp.187 - 202en_US
dc.identifier.issn1523-0864-
dc.identifier.issn1557-7716-
dc.identifier.urihttp://online.liebertpub.com/doi/abs/10.1089/ars.2010.3190-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/66205-
dc.description.abstractHepatic steatosis, a hepatic component of metabolic syndrome, is common and may progress to steatohepatitis and cirrhosis. The liver X receptor-alpha (LXR alpha)-sterol regulatory element binding protein-1c (SREBP-1c) pathway plays a key role in hepatic steatosis. This study investigated the potential of ajoene, a stable garlic by-product, to inhibit high fat diet (HFD)-induced hepatic steatosis and the underlying mechanism. Ajoene treatment attenuated fat accumulation and induction of lipogenic genes in the liver of HFD-fed mice. Blood biochemical analyses and histopathologic examinations showed that ajoene prevented liver injury with the inhibition of oxidative stress, as evidenced by thiobarbituric acid reactive substances formation and nitrotyrosinylation. Moreover, ajoene treatment inhibited LXR alpha agonist (T0901317)-mediated SREBP-1c activation, and transactivation of the lipogenic target genes in hepatocytes. Ajoene was found to activate AMP-activated protein kinase (AMPK) via LKB1, responsible for the inhibition of p70 ribosomal S6 kinase-1 (S6K1). The ability of ajoene to repress T0901317-induced SREBP-1c expression was antagonized by inhibition of AMPK or activation of S6K1, supporting the role of these kinases in the antisteatotic effect. Our results demonstrate that ajoene has an effect of activating AMPK through LKB1 and inhibit S6K1 activity, contributing to the prevention of SREBP-1c-mediated hepatic lipogenesis via the inhibition of LXR alpha activity. Antioxid Redox Signal. 14, 187-202.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea grant funded by the Korea government (MEST)(No. 2010-0001706), Korea. CYH would lik 0000090D e to thank the Seoul Science Fellowship program.en_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USAen_US
dc.subjectLIVER-X-RECEPTORen_US
dc.subjectELEMENT-BINDING PROTEIN-1Cen_US
dc.subjectNITRIC-OXIDE SYNTHASEen_US
dc.subjectS6 KINASE-1 PATHWAYen_US
dc.subjectINSULIN-RESISTANCEen_US
dc.subjectLIPID-METABOLISMen_US
dc.subjectHEPG2 CELLSen_US
dc.subjectLXR-ALPHAen_US
dc.subjectSTRESSen_US
dc.subjectMICEen_US
dc.titleAjoene, A Stable Garlic By-Product, Inhibits High Fat Diet-Induced Hepatic Steatosis and Oxidative Injury Through LKB1-Dependent AMPK Activationen_US
dc.typeArticleen_US
dc.relation.volume14-
dc.identifier.doi10.1089/ars.2010.3190-
dc.relation.page187-202-
dc.relation.journalANTIOXIDANTS & REDOX SIGNALING-
dc.contributor.googleauthorHan, Chang Yeob-
dc.contributor.googleauthorKi, Sung Hwan-
dc.contributor.googleauthorKim, Young Woo-
dc.contributor.googleauthorNoh, Kyoung-
dc.contributor.googleauthorLee, Da Yeon-
dc.contributor.googleauthorKang, Bomi-
dc.contributor.googleauthorRyu, Jae-Ha-
dc.contributor.googleauthorJeon, Raok-
dc.contributor.googleauthorKim, Eun Hyun-
dc.contributor.googleauthorHwang, Se Jin-
dc.relation.code2011214099-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhwangsj-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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