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Regulatory systems for hypoxia-inducible gene expression in ischemic heart disease gene therapy

Title
Regulatory systems for hypoxia-inducible gene expression in ischemic heart disease gene therapy
Author
이민형
Keywords
Hypoxia; Gene therapy; Gene regulation; Ischemic heart disease; ENDOTHELIAL GROWTH-FACTOR; ACUTE MYOCARDIAL-INFARCTION; DEPENDENT DEGRADATION DOMAIN; WATER-SOLUBLE LIPOPOLYMER; RNA-BINDING-PROTEIN; BREAST-CANCER CELLS; HEME OXYGENASE-1; TUMOR-CELLS; IN-VIVO; FACTOR 1-ALPHA
Issue Date
2011-01
Publisher
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Citation
ADVANCED DRUG DELIVERY REVIEWS 권: 63 호: 8 페이지: 678-687
Abstract
Ischemic heart diseases are caused by narrowed coronary arteries that decrease the blood supply to the myocardium. In the ischemic myocardium, hypoxia-responsive genes are up-regulated by hypoxia-inducible factor-1 (HIF-1). Gene therapy for ischemic heart diseases uses genes encoding angiogenic growth factors and anti-apoptotic proteins as therapeutic genes. These genes increase blood supply into the myocardium by angiogenesis and protect cardiomyocytes from cell death. However, non-specific expression of these genes in normal tissues may be harmful, since growth factors and anti-apoptotic proteins may induce tumor growth. Therefore, tight gene regulation is required to limit gene expression to ischemic tissues, to avoid unwanted side effects. For this purpose, various gene expression strategies have been developed for ischemic-specific gene expression. Transcriptional, post-transcriptional, and post-translational regulatory strategies have been developed and evaluated in ischemic heart disease animal models. The regulatory systems can limit therapeutic gene expression to ischemic tissues and increase the efficiency of gene therapy. In this review, recent progresses in ischemic-specific gene expression systems are presented, and their applications to ischemic heart diseases are discussed. (C) 2011 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0169409X1100007X?via%3Dihubhttp://hdl.handle.net/20.500.11754/66190
ISSN
0169-409x
DOI
10.1016/j.addr.2011.01.003
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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