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Claudin-11 expression increased in spermatogenic defect in human testes

Title
Claudin-11 expression increased in spermatogenic defect in human testes
Author
계명찬
Keywords
Claudin-11; human; Sertoli cells; testis; tight junction
Issue Date
2011-01
Publisher
Elsevier Science B.V., Amsterdam.
Citation
FERTILITY AND STERILITY 권: 95 호: 1 페이지: 385-388
Abstract
Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis. (Fertil Steril (R) 2011;95:385-8. (C) 2011 by American Society for Reproductive Medicine.)
URI
http://www.fertstert.org/article/S0015-0282(10)02411-8/fulltexthttp://hdl.handle.net/20.500.11754/66117
ISSN
0015-0282; 1556-5653
DOI
10.1016/j.fertnstert.2010.08.023
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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