Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-04-13T09:55:01Z | - |
dc.date.available | 2018-04-13T09:55:01Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | CELL DEATH AND DIFFERENTIATION, 2011, 18(12), P.1865-1875 | en_US |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://www.nature.com/articles/cdd201157 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/65910 | - |
dc.description.abstract | Following DNA damage, p53 translocates to the cytoplasm and mitochondria, where it triggers transcription-independent apoptosis by binding to Bcl-2 family proteins. However, little is known about how this exonuclear function of p53 is regulated. Here, we identify and characterize a p53-interacting protein called Hades, an E3 ligase that interacts with p53 in the mitochondria. Hades reduces p53 stability via a mechanism that requires its RING-finger domain with ubiquitin ligase activity. Hades polyubiquitinates p53 in vitro independent of Mdm2 and targets a critical lysine residue in p53 (lysine 24) distinct from those targeted by Mdm2. Hades inhibits a p53-dependent mitochondrial cell death pathway by inhibiting p53 and Bcl-2 interactions. These findings show that Hades-mediated p53 ubiquitination is a novel mechanism for negatively regulating the exonuclear function of p53. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.subject | Tumour-suppressor proteins | en_US |
dc.subject | Ubiquitin ligases | en_US |
dc.subject | Ubiquitylation | en_US |
dc.title | E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53 | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.1038/cdd.2011.57 | - |
dc.relation.page | 1865-1875 | - |
dc.relation.journal | CELL DEATH AND DIFFERENTIATION | - |
dc.contributor.googleauthor | Jung, J. H. | - |
dc.contributor.googleauthor | Bae, S. | - |
dc.contributor.googleauthor | Lee, J. Y. | - |
dc.contributor.googleauthor | Woo, S. R. | - |
dc.contributor.googleauthor | Cha, H. J. | - |
dc.contributor.googleauthor | Yoon, Y. | - |
dc.contributor.googleauthor | Suh, K. S. | - |
dc.contributor.googleauthor | Lee, S. J. | - |
dc.contributor.googleauthor | Park, I. C. | - |
dc.contributor.googleauthor | Jin, Y. W. | - |
dc.relation.code | 2011201738 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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