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dc.contributor.author김근호-
dc.date.accessioned2018-04-13T08:54:57Z-
dc.date.available2018-04-13T08:54:57Z-
dc.date.issued2011-12-
dc.identifier.citationElectrolytes & Blood Pressure, 2011, 9(2), P.55~62en_US
dc.identifier.issn1738-5997-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.5049/EBP.2011.9.2.55-
dc.description.abstractProteinuria is a major promoter that induces tubulointerstitial injury in glomerulopathy. Dietary salt restriction may reduce proteinuria, although the mechanism is not clear. We investigated the effects of dietary salt restriction on rat kidneys in an animal model of glomerular proteinuria. Male Sprague-Dawley rats were used and divided into 3 groups: vehicle-treated normal-salt controls, puromycin aminonucleoside (PA)-treated normal-salt rats, and PA-treated low-salt rats. PA was given at a dose of 150 mg/kg BW at time 0, followed by 50 mg/kg BW on days 28, 35, and 42. Sodium-deficient rodent diet with and without additional NaCl (0.5%) were provided for normal-salt rats and low-salt rats, respectively. On day 63, kidneys were harvested for histopathologic examination and immunohistochemistry. PA treatment produced overt proteinuria and renal damage. Dietary salt restriction insignificantly reduced proteinuria in PA-treated rats, and PA-treated low-salt rats had lower urine output and lower creatinine clearance than vehicle-treated normal-salt controls. When tubulointerstitial injury was semiquantitatively evaluated, it had a positive correlation with proteinuria. The tubulointerstitial injury score was significantly increased by PA treatment and relieved by low-salt diet. ED1-positive infiltrating cells and immunostaining for interstitial collagen III were significantly increased by PA treatment. These changes appeared to be less common in PA-treated low-salt rats, although the differences in PA-treated normal-salt versus low-salt rats did not reach statistical significance. Our results suggest that renal histopathology in PA nephrosis may potentially be improved by dietary salt restriction. Non-hemodynamic mechanisms induced by low-sodium diet might contribute to renoprotection.en_US
dc.language.isoenen_US
dc.publisherThe Korean Society of Electrolyte Metabolismen_US
dc.subjectpuromycinen_US
dc.subjectdieten_US
dc.subjectsodium-restricteden_US
dc.subjectproteinuriaen_US
dc.subjectkidneyen_US
dc.titleEffects of dietary salt restriction on puromycin aminonucleoside nephrosis: Preliminary dataen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume9-
dc.identifier.doi10.5049/EBP.2011.9.2.55-
dc.relation.page55-62-
dc.relation.journalElectrolyte and Blood Pressure-
dc.contributor.googleauthorGheun-Ho, Kim-
dc.contributor.googleauthorSua, Kim-
dc.contributor.googleauthorJoon-Sung, Park-
dc.contributor.googleauthorChor Ho, Jo-
dc.relation.code2012231235-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkimgh-


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