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Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes

Title
Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes
Author
임동우
Keywords
Carcinoembryonic Antigen; blood; Gold; chemistry; Humans; Immunoassay; methods; Lung Neoplasms; Metal Nanoparticles; Spectrum Analysis, Raman; Time Factors; Tumor Markers; Biological; alpha-Fetoproteins; analysis
Issue Date
2011-12
Publisher
Royal Society of Chemistry
Citation
Chemical Communications, 14 December 2011, 47(46), p.12515-12517
Abstract
A quick and reproducible SERS-based immunoassay, using functionalized hollow gold nanospheres and magnetic beads, has been developed. Here, a simultaneous detection of dual cancer markers in blood serum has been achieved under a single excitation wavelength. The accuracy and sensitivity for clinical sera from five patients confirms their diagnostic feasibility. Graphic Abstract A quick and reproducible SERS-based immunoassay, using hollow gold nanospheres and magnetic beads, has been developed. Here, a simultaneous detection of dual cancer markers in blood serum has been achieved under a single excitation wavelength. The accuracy and sensitivity for clinical sera from five patients confirms their diagnostic feasibility.
URI
http://pubs.rsc.org/en/Content/ArticleLanding/2011/CC/c1cc15707h#!divAbstracthttp://hdl.handle.net/20.500.11754/65868
ISSN
1359-7345; 1364-548X
DOI
10.1039/c1cc15707h
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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