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dc.contributor.author최한곤-
dc.date.accessioned2018-04-13T00:29:33Z-
dc.date.available2018-04-13T00:29:33Z-
dc.date.issued2016-07-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 144, Page. 327-334en_US
dc.identifier.issn0927-7765-
dc.identifier.issn1873-4367-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S092777651630279X-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/65736-
dc.description.abstractAlbumin has gained considerable interest as a material for fabricating nanoparticulate systems due to its biomedical advantages, such as biocompatibility and chemical functionality. Here, we report a new pH-sensitive albumin nanocomplex prototype with a zinc-imidazole coordination bond. Albumin was conjugated with 1-(3-aminopropyl)imidazole and mPEG(10kDa)-NHS, and the resulting albumin conjugate (PBI) was then modified with either Cy5.5 or BHQ-3. The newly formed albumin nanocomplex (C/BQ-PBI Zn NCs: similar to 116 nm) system was facilely self-assembled around pH 7.4 in the presence of Zn2+, but it quickly disassembled in an acidic environment (similar to pH 5.0). Based on this pH-sensitivity, C/BQ-PBI Zn NCs emitted strong near-infrared fluorescence and released Zn2+, turning "off" at pH similar to 7.4 (e.g., plasma) and "on" at pH similar to 5.0 (e.g., endo/lysosomes in tumor cells) on account of fluorescence resonance energy transfer. C/BQ-PBI Zn NCs displayed significant cytotoxicity due to an increase in cellular. Zn2+ in response to endosomal pH (similar to 5.0) in breast cancer MCF-7 cells and lung adenocarcinoma A549 cells. Particularly, confocal laser scanning microscopic images showed a strong fluorescence signal caused by the disassembly of C/BQ-PBI Zn NCs in the endosomal region of MCF-7 cells. Based on these results, we believe that this albumin nanocomplex is an attractive biocompatible tumor targeting probe carrier for the theranostic purpose. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (NRF-2014R1A2A2A05002133).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectAlbuminen_US
dc.subjectNanocomplexen_US
dc.subjectpH-sensitivityen_US
dc.subjectSelf-assemblyen_US
dc.subjectTumor targetingen_US
dc.subjectZinc-imidazole interactionen_US
dc.titleAn albumin nanocomplex-based endosomal pH-activatable on/off probe systemen_US
dc.typeArticleen_US
dc.relation.volume144-
dc.identifier.doi10.1016/j.colsurfb.2016.04.022-
dc.relation.page327-334-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorLee, C-
dc.contributor.googleauthorLee, S-
dc.contributor.googleauthorThao, LQ-
dc.contributor.googleauthorHwang, HS-
dc.contributor.googleauthorKim, JO-
dc.contributor.googleauthorLee, ES-
dc.contributor.googleauthorOh, KT-
dc.contributor.googleauthorShin, BS-
dc.contributor.googleauthorChoi, HG-
dc.contributor.googleauthorYoun, YS-
dc.relation.code2016001589-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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