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Effect of early prepubertal exposure to bisphenol A on the onset of puberty, ovarian weights and estrous cycle in female mice

Title
Effect of early prepubertal exposure to bisphenol A on the onset of puberty, ovarian weights and estrous cycle in female mice
Author
계명찬
Keywords
Bisphenol A; Endocrine Disruptors; Puberty; Female; Mice
Issue Date
2011-12
Publisher
The Korean Society for Reproductive Medicine
Citation
Clinical and Experimental Reproductive Medicine, 2011, 38(2), P.75-81
Abstract
Objective: Bisphenol A (BPA) is a chemical used extensively to manufacture plastics and epoxy resin liners for food and beverage cans. BPA, with properties similar to estrogen, has endocrine-disrupting effects. In the present study, we examined the effects of early prepubertal BPA exposure on the onset of puberty and reproductive parameters such as estrous cycle and reproductive organ weights in female mice. Methods: Female mice were injected subcutaneously at postnatal day (PND) 8 with BPA (0.1, 1, 10, 100 mg/kg) in sesame oil or with sesame oil alone. Body weight was measured from PND 10 to 70. Vaginal opening and estrous cycle were monitored from PND 20 to 29. Animals were sacrificed at PND 25, 30, and 70, and the ovary and uterus weights were measured. Results: Early prepubertal exposure to BPA (10 and 100 mg/kg) significantly decreased body weight from PND 18 to 30. BPA treated mice at testing dose levels showed early opening of the vagina compared to the control group. The number of estrous cycle and days of estrus were significantly decreased in high dose (100 mg/kg) BPA treated mice. The ovary weight at PND 25 and 30 was significantly decreased in all BPA treatment groups. Conclusion: Early prepubertal exposure to BPA accelerated the onset of puberty but decreased reproductive parameters in female mice.
URI
https://synapse.koreamed.org/DOIx.php?id=10.5653/cerm.2011.38.2.75
ISSN
2233-8233
DOI
10.5653/cerm.2011.38.2.75
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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