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dc.contributor.author문효방-
dc.date.accessioned2018-04-09T07:57:18Z-
dc.date.available2018-04-09T07:57:18Z-
dc.date.issued2016-06-
dc.identifier.citationENVIRONMENTAL POLLUTION, v. 214, Page. 568-574en_US
dc.identifier.issn0269-7491-
dc.identifier.issn1873-6424-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0269749116303177-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/65500-
dc.description.abstractTris(2-butoxyethyl) phosphate (TBEOP), a widely used organophosphate flame retardant, has frequently been detected both in the environment and the biota. However, limited information is available on the effects of TBEOP on the endocrine system and its underlying mechanisms. We exposed adult zebrafish pairs to TBEOP at concentrations of 0, 2.1,11, and 118 mu g/L for 21 d, and investigated the effects on gene transcription and hormone production related to the hypothalamic-pituitary-gonadal (HPG) axis, and on reproduction. The adverse effects on the F1 generation were further examined. In male fish, plasma concentrations of 17 beta-estradiol were significantly increased along with up-regulation of cyp19a. Exposure to TBEOP at 118 mu g/L to a significant decrease in average egg production. Exposure of the F0 generation to TBEOP delayed hatching and lowered hatching rates in the F1 generation. The results demonstrate that exposure to TBEOP at environmentally relevant concentration levels could affect the sex hormone balance by altering regulatory circuits of the HPG axis, eventually leading to disruption of reproductive performance and the development of offspring. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipThis study was supported by National Research Foundation of Korea (NRF; Project no. 2013R1A1A2012182). We would like to thank S. Jang, B.K. Kim, and N.K. Jung for technical assistance in toxicity testing.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectTBEOPen_US
dc.subjectOrganophosphate flame retardantsen_US
dc.subjectEndocrine disruptionen_US
dc.subjectHPG axisen_US
dc.subjectZebraflshen_US
dc.subjectORGANOPHOSPHORUS FLAME RETARDANTSen_US
dc.subjectPOLYBROMINATED DIPHENYL ETHERSen_US
dc.subjectDISRUPTING COMPOUNDSen_US
dc.subjectMASS-SPECTROMETRYen_US
dc.subjectDRINKING-WATERen_US
dc.subjectAXISen_US
dc.subjectEXPRESSIONen_US
dc.subjectHORMONESen_US
dc.subjectPHARMACEUTICALSen_US
dc.subjectEMBRYOS/LARVAEen_US
dc.titleEffects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)en_US
dc.typeArticleen_US
dc.relation.volume214-
dc.identifier.doi10.1016/j.envpol.2016.04.049-
dc.relation.page568-574-
dc.relation.journalENVIRONMENTAL POLLUTION-
dc.contributor.googleauthorKwon, Bareum-
dc.contributor.googleauthorShin, Hyejin-
dc.contributor.googleauthorMoon, Hyo-Bang-
dc.contributor.googleauthorJi, Kyunghee-
dc.contributor.googleauthorKim, Ki-Tae-
dc.relation.code2016000994-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING-
dc.identifier.pidhbmoon-


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